Clinical diagram of periorbital anatomy showing PDRN polynucleotide injection technique for under-eye skin quality improvement

PDRN for Under-Eye Rejuvenation: Protocol and Product Selection

The under-eye and periorbital zone is simultaneously the most frequently cited aesthetic concern in consultation and the zone where practitioners most often choose the wrong product. Standard HA skin boosters — which work excellently for the cheeks, forehead, and neck — cause persistent lower eyelid puffiness in the periorbital zone because their hydrophilicity draws water into a space with extremely limited lymphatic drainage and 0.3–0.5mm of overlying skin.