Scientific illustration of polynucleotide DNA chain fragments stimulating fibroblast cells in skin tissue for collagen regeneration

Polynucleotides and PDRN: The Complete Practitioner's Guide

Polynucleotides — sold under a variety of brand names and delivered through a growing range of injection products — have become one of the most talked-about categories in UK aesthetic medicine. They are also one of the most misunderstood. Practitioners encounter them under different terminology (PDRN, PN, polynucleotide, polydeoxyribonucleotide), from multiple manufacturers, with variable claimed mechanisms, and with an evidence base that ranges from well-established to preliminary depending on the specific application and product.