NMN Signal Starter System  |  3 mL × 1 Vial / Box  |  Republic of Korea

NMN Signal. Awakened Vitality.

VODA DERM NMN System is a precision-designed NMN conditioning system for the first step of skin vitality care. Built around the NMN to NAD+ vitality pathway, it connects four sequential mechanisms — Activate, Communicate, Energize, and Refine — into one coherent signal system.

This is not a simple NMN ampoule. VODA DERM NMN System is designed to activate and shape the flow of skin vitality through a structured multi-ingredient approach, targeting tired-looking, dull, and low-vitality skin conditions.

Why NMN Signal Care?

When skin condition declines, skin begins to look tired.

The first step of skin vitality care begins not with simple supplementation, but with preparing the flow of skin condition. VODA DERM NMN System is designed to support NMN-based skin vitality signals for tired-looking skin conditions.

Signs that indicate a vitality signal is needed:

• Low Vitality: Skin condition that needs a vitality signal

• Dull Impression: Skin that needs a clearer, refined look

• Uneven Texture: Skin that appears unbalanced and less refined

• Reduced Elasticity: Skin that needs an energized-looking impression

Why NAD+ Signal Matters

NAD+ is an essential coenzyme governing cellular energy metabolism and skin homeostasis.

However, as we age, skin NAD+ levels deplete rapidly, acting as a fundamental cause of reduced skin vitality. Research shows NAD+ levels fall from 100% at newborn to approximately 32% in young adults (~20s), and further to approximately 13% by middle age (~40–60s).

Source: Peluso A, et al. Age-Dependent Decline of NAD+. Nutrients 2022;14(1):101. PMC8747183.

Core Functions of NAD+

Mitochondria — Cellular Energy Metabolism

Supports mitochondrial energy metabolism to awaken the energy flow of skin cells.

PARP1 — DNA Repair Pathway

Acts as a key substrate for PARP in DNA repair pathways, activating the skin's defense against oxidative stress.

SIRT1 — Sirtuin Activation (Anti-Aging Core Pathway)

Acts as an essential cofactor in aging-related sirtuin pathways, supporting skin density and resilience against intrinsic aging.

The above descriptions are based on published scientific studies related to NMN and NAD+ biology. They refer to the general characteristics of the ingredient and do not represent the direct clinical efficacy of the finished product.

4-Step NMN Signal Conditioning System

A 4-step signal system designed to begin with NMN and shape the flow of skin vitality.

VODA DERM NMN System is designed around NMN, connecting the NAD+ pathway, Grape Phyto-Exosome, Energy Co-Factors, and Bio-Polypeptide refinement as one precision system designed to activate, communicate, energize, and refine the flow of skin vitality.

Step 01 — ACTIVATE: NMN → NAD+ Vitality Pathway

A skin vitality pathway from NMN to NAD+.

Why NMN?

• NAD+ is a key coenzyme that drives the vitality flow of skin cells.

• NMN is one of the most direct key precursors for NAD+ biosynthesis, converted into NAD+ in a single step by NMNAT enzymes to ignite skin vitality.

• VODA DERM NMN System is designed around the NMN → NAD+ pathway to shape an awakened vitality flow for tired-looking skin conditions.

The Synergy of NMN & NAD+

Combining direct NAD+ support with NMN-driven intracellular synthesis for immediate and sustained skin vitality.

Research indicates that combining direct NAD+ supply with NMN-driven biosynthesis, acting through complementary routes including the CD38/NAD+/SIRT1 axis, supports a greater cellular NAD+ response than either ingredient alone.

Source: Kang S, et al. Cells 2024;13(21):1799; Conlon N, Kang S. Nutrients 2023;15(2):445.

Step 02 — COMMUNICATE: Grape Phyto-Exosome Signal

Optimization of Intercellular Signaling.

VODA DERM has established an active delivery system utilizing grape callus-derived Phyto-Exosomes to improve the transdermal permeability of high-purity NMN. This system functions as an intercellular signaling mediator to drive homeostasis in the dermal microenvironment.

Distinctive Features of Phyto-Exosomes

SIZE — Nano-Scale

50–150 nm natural lipid bilayer structure, optimized for skin barrier penetration.

CARGO — Bioactive Signal

Encapsulates proteins and antioxidant phytochemicals to directly activate cellular signal networks.

SAFETY — Low Immunogenicity

60–80% lower immunogenicity compared to mammalian exosomes, eliminating immune rejection risk.

SOURCE — Grape Callus

Plant stem cell extraction technology concentrates active ingredients into exosomes, maximising absorption.

How Phyto-Exosomes Work

• Step 1 — Skin Cell Internalization: Exosomes are absorbed into skin cells, delivering their contents directly inside the cells.

• Step 2 — Signal Activation & Regeneration Promotion: miRNA, proteins, and NMN activate cellular signalling, promoting regeneration and skin vitality.

Step 03 — ENERGIZE: Energy Co-Factor Support

Fuel the flow. Complete the signal.

VODA DERM NMN System adds co-factor support to sustain the NMN → NAD+ vitality pathway. Rather than relying on NMN alone, the formula incorporates key metabolic co-factors that work alongside the NAD+ pathway to maintain cellular energy balance.

Coenzyme A — Energy-Related Conditioning Support

Supports energy-related conditioning and plays a central role in cellular metabolic processes.

Thiamine Diphosphate — Metabolic Co-Factor

A metabolic co-factor concept ingredient that supports key energy metabolism pathways.

Inositol — Balanced Skin Condition Support

Supports a balanced skin condition and contributes to a stable cellular environment.

Sodium Gluconate — Formula Balance Support

Supports overall formula balance and helps maintain a stable product environment.

Step 04 — REFINE: Bio-Polypeptide Conditioning

5-Polypeptide Complex for skin impression refinement.

Following cellular activation and energy supply via NMN, the robust reorganisation of the epidermal and dermal physical structures is essential. The REFINE stage utilises 5 types of recombinant peptides (sh-Polypeptides) to restore the compromised skin barrier and matrix architecture, supporting the formation of a smooth skin condition.

sh-Polypeptide-7 — hGH Fragment

Cell growth & regeneration signal.

sh-Polypeptide-5 — TGF-β3 Analog

Cell differentiation & ECM remodelling.

sh-Polypeptide-4 — SCF Analog

Stem cell activation & epidermal renewal.

sh-Polypeptide-2 — IGF-1 Analog

Collagen & elastin synthesis support.

sh-Polypeptide-16 — BMP-2 Analog

Dermal structure refinement & signalling.

Areas of Skin Quality Addressed:

• Regeneration

• Texture

• Collagen

• Skin Barrier

• Anti-Aging

Recommended For

Skin that needs a vitality signal — from the inside out.

• Low skin vitality — skin that looks tired and lacks radiance

• Dull skin impression — skin that needs a clearer, more refined look

• Uneven texture — skin that appears unbalanced and less refined

• Reduced elasticity — skin that needs an energised-looking impression

• Skin conditions associated with age-related NAD+ decline

• Patients seeking a structured skin vitality programme

Recommended Application Protocol

Overview

Method 1 — MTS (Micro-Needling)

MTS creates micro-channels on the skin surface to maximise absorption of active ingredients across the epidermal–dermal layers, and stimulates collagen production through the natural healing process.

Method 2 — Dermashine

Dermashine uses 9-pin / 5-pin multi-needles to uniformly and rapidly inject product across the entire face. Faster procedure with less pain and bruising compared to manual injection.

Method 3 — Manual Injection

Manual injection involves the physician precisely targeting the dermis with a syringe. Most effective for localised areas such as eye corners, mouth lines, and nasolabial folds, with minimal product loss.

Product Specifications

For registered practitioners only. This product is intended for professional use by qualified and licensed practitioners. Not for retail sale.

Results disclaimer: Images are for reference only and do not represent the results of any specific product. Actual results may vary depending on the individual.

Scientific references: Descriptions based on published scientific studies related to NMN and NAD+ biology. They refer to the general characteristics of the ingredient and do not represent the direct clinical efficacy of the finished product.

All Celmade shipments originate from South Korea. We help the main features of sending products to more than 50 countries all around the world.

Shipping Policy

• We ship worldwide using DHL, FedEx, and EMS for fast and secure delivery.
• Processing time: 1-3 business days (excluding weekends & holidays).
• Delivery time: 3-10 business days, depending on location.

Import & Customs Policy

• Customers outside South Korea are responsible for all import duties, customs clearance, and local regulations.
• Bulk orders may require import licenses or regulatory approvals in certain countries.
• For U.S. buyers: Some aesthetic medical products (e.g., Botilinum toxin, Fillers) may require FDA clearance. Customers must check local requirements before purchasing.
• If the package is delayed, held, or returned due to customs, Celmade.co is not responsible for reshipping or refunds.

Restricted & High-Risk Shipments

• We do not ship to countries with import restrictions on certain aesthetic medical products.
• If your order is rejected by customs, it is the buyer’s responsibility to arrange clearance or return shipping.

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